Profile of circulating MicroRNAs in low density lipoprotein uptake: literature review
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چکیده
منابع مشابه
Effect of Lycopene on Formation of Low Density Lipoprotein-Copper Complex in Copper Catalyzed Peroxidation of Low Density Lipoprotein, as in vitro Experiment
Background: A great deal of evidence has indicated that oxidatively modified LDL plays a critical role in the initiation and progression of atherosclerosis. Antioxidants that can prevent LDL oxidation may act as antiatherogens. Copper is a candidate for oxidizing LDL in atherosclerotic lesions. The binding of copper ions to LDL is usually thought to be a prerequisite for LDL oxidation by copper...
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Oxidized low-density lipoprotein (OxLDL) and autoantibodies to OxLDL (aOxLDL) are implicated in the development of atherosclerosis. The objective of this study was to determine the importance of these factors in hypertension, a major risk factor for atherosclerosis. Samples were obtained from 111 men with established hypertension (diastolic pressure >95 mmHg) from the Swedish component of an on...
متن کاملCarbohydrate composition of circulating multiple-modified low-density lipoprotein
Atherogenic modification of low-density lipoprotein (LDL) plays a crucial role in the pathogenesis of atherosclerosis, as modified LDL, but not native LDL, induces pronounced accumulation of cholesterol and lipids in the arterial wall. It is likely that LDL particles undergo multiple modifications in human plasma: desialylation, changes in size and density, acquisition of negative electric char...
متن کاملInvolvement of the macrophage low density lipoprotein receptor-binding domains in the uptake of oxidized low density lipoprotein.
Macrophages, unlike most other cells, possess both low density lipoprotein (LDL) and scavenger receptors. The scavenger receptor has been shown to mediate the uptake of oxidized LDL (ox-LDL), which ultimately leads to cholesterol loading of the macrophages. The present study was undertaken to define epitopes on ox-LDL that are important for lipoprotein binding to macrophages and to ascertain wh...
متن کاملEnhanced macrophage uptake of low density lipoprotein after self-aggregation.
Incubation of mouse peritoneal macrophages with native human low density lipoprotein (LDL) did not cause any significant storage of intracellular cholesteryl esters. However, when the LDL was subjected to brief (30-second) vortexing, it formed self-aggregates that were rapidly ingested and degraded by macrophages, converting them to cholesteryl ester-rich foam cells. Such aggregates were as pot...
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ژورنال
عنوان ژورنال: Revista Eletrônica Acervo Saúde
سال: 2021
ISSN: 2178-2091
DOI: 10.25248/reas.e4546.2021